This study uses a neoclassical framework aiming to explain why different changes in foreign policy towards Cuba has occurred under the Trump-era. The main research question of the study is therefore: To what extent can neo-classical realism explain US policy changes towards Cuba during Trump's 2017-2021 term? The study identified three major changes that occured during the set time period that has been analysed through a neoclassical realist perspective. The material consists of a wide range from government documentation, reports, remarks, newspaper articles, academic work, tweets and more, to get a complete picture as possible. Three intervening variables grounded in neoclassical theory has been set up to analyse and find the material. The analysis concluded that domestic politics can have broad effect on foreign policy, which the neoclassical realism theory can identify.