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Activation of the Complement and Coagulation Systems in the Small Airways in Asthma
University of Gothenburg, Sweden.
PExA AB, Sweden.
Uppsala University, Sweden.
Sahlgrenska University Hospital, Sweden;University of Gothenburg, Sweden.ORCID iD: 0000-0002-4387-4096
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2023 (English)In: Respiration, ISSN 0025-7931, E-ISSN 1423-0356, Vol. 102, no 8, p. 621-631Article in journal (Refereed) Published
Abstract [en]

Background: Several studies have shown the importance of the complement and coagulation systems in the pathogenesis of asthma. Objectives: We explored whether we could detect differentially abundant complement and coagulation proteins in the samples obtained from the small airway lining fluid by collection of exhaled particles in patients with asthma and whether these proteins are associated with small airway dysfunction and asthma control. Method: Exhaled particles were obtained from 20 subjects with asthma and 10 healthy controls (HC) with the PExA method and analysed with the SOMAscan proteomics platform. Lung function was assessed by nitrogen multiple breath washout test and spirometry. Results: 53 proteins associated with the complement and coagulation systems were included in the analysis. Nine of those proteins were differentially abundant in subjects with asthma as compared to HC, and C3 was significantly higher in inadequately controlled asthma as compared to well-controlled asthma. Several proteins were associated with physiological tests assessing small airways. Conclusions: The study highlights the role of the local activation of the complement and coagulation systems in the small airway lining fluid in asthma and their association with both asthma control and small airway dysfunction. The findings highlight the potential of complement factors as biomarkers to identify different sub-groups among patients with asthma that could potentially benefit from a therapeutic approach targeting the complement system.

Place, publisher, year, edition, pages
S. Karger, 2023. Vol. 102, no 8, p. 621-631
Keywords [en]
Asthma control, Asthma, Complement system, Coagulation, Small airways, Exhaled particles
National Category
Immunology in the medical area
Research subject
Biomedical Sciences, Immunology
Identifiers
URN: urn:nbn:se:lnu:diva-123593DOI: 10.1159/000531374ISI: 001026727600001PubMedID: 37423212Scopus ID: 2-s2.0-85165921610OAI: oai:DiVA.org:lnu-123593DiVA, id: diva2:1786993
Available from: 2023-08-10 Created: 2023-08-10 Last updated: 2023-11-07Bibliographically approved

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Nilsson Ekdahl, Kristina

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Vanfleteren, Lowie E. G. W.Olsson, Henric K.Nilsson Ekdahl, Kristina
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