In recent years much about the modeling and understanding of various types of disease spreading and epidemic behavior have been studied. In principle one can distinguish two types of models for disease spread. On the one hand there is the classical SIR-model from Kermack and McKendrick [1] which describes the time evolution of the number of susceptible (S), infected (I) and recovered (R) individuals by a system of ordinary differential equations. This model has been developed and extended exhaustively in the last 90 years. Among those extensions are the introduction of new compartments to model vector-bourne diseases, see e.g. [2], delay equations to model incubation time, e.g. [3], models considering the age and wealth structure etc. Recently, models with fractional derivatives have also been considered[4]. Unfortunately, we are unable to provide a detailed account concerning this subject and refer the interested reader to [5]. A main drawback of the models described above is that they do not provide any information about the spatial spread of a disease. Nevertheless, there have been various approaches to link many different SIR-areas to obtain spatial behavior. In the SIR-model case, an advection-diffusion equation has been identified as the limiting equation,see e.g. [6]. Another approach in incorporating spatial information for the SIR-model may also be found in [7]. Although the SIR-model and all its extensions are very flexible in describing the different aspects of disease dynamics, the modeling assumptions of the disease spread is purely on the macroscopic level. However, for many different diseases the infection mechanism is only known on the microscopic, i.e., particle-to-particle or individ uumto-individuum level. One way to consider both microscopical modeling and spatial resolution is to describe of the disease dynamics by means of an interacting particle system with suitable interaction potentials. Fundamental in this area are dynamics in so-called marked configuration spaces [8]. These techniques together with a proper scaling of the microscopic system,the so-called Vlasov scaling, have been recently used to model the dynamics of cancer cells [9]. In our approach the components of particle configurations consist of susceptible and infected/infective particles that interact with one another. One may also easily incorporate other types of particles to model recovery or short time immunity. Themicroscopic dynamics then results from suitable ”spin-flip”-processes (particle changes the type).This article shows first numerical results for the SIS-system without movement. The SIS-system allows infective/infected particles to recover and become susceptible again. The numerical methods are based on the analysis provided in [10].