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Increased S100B in blood after cardiac surgery is a powerful predictor of late mortality
Lund University Hospital, Sweden.
Lund University Hospital, Sweden.
Lund University, Sweden. (Avdelningen för klinisk psykologi)ORCID iD: 0009-0001-3013-8540
Lund University, Sweden.
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2003 (English)In: Annals of Thoracic Surgery, ISSN 0003-4975, E-ISSN 1552-6259, Vol. 75, no 1, p. 162-168Article in journal (Refereed) Published
Sustainable development
SDG 3: Ensure healthy lives and promote well-being for all at all ages
Abstract [en]

BackgroundLong-term outcome in patients who suffered stroke after undergoing a cardiac operation has been investigated sparingly, but increased long-term mortality has been reported. S100B is a biochemical marker of brain cell ischemia and blood–brain barrier dysfunction. The aim of this investigation was to record the long-term mortality in consecutive patients undergoing cardiac operations and to explore whether increased concentrations of S100B in blood had a predictive value for mortality.MethodsProspectively collected clinical variables, including S100B, in 767 patients who survived more than 30 days after a cardiac operation, were analyzed with actuarial survival analysis and 678 patients were analyzed with Cox multiple regression analysis.ResultsForty-nine patients (6.4%) were dead at follow-up (range, 18 to 42 months); 11.5% (88 of 767 patients) had elevated S100B 2 days after operation (range, 38 to 42 hours). The probability for death at follow-up was 0.239 if the S100B level was more than 0.3 μg/L, and 0.041 if it was less than 0.3 μg/L. The clinical variables independently associated with mortality were preoperative renal failure, preoperative low left ventricular ejection fraction, emergency operation, severe postoperative central nervous system complication, and elevated S100B values, which turned out to be the most powerful predictor.ConclusionsEven slightly elevated S100B values in blood 2 days after cardiac operation imply a bad prognosis for outcome, and especially so in combination with any central nervous system complication.

Place, publisher, year, edition, pages
2003. Vol. 75, no 1, p. 162-168
National Category
Clinical Medicine Anesthesiology and Intensive Care Clinical Medicine Surgery Cardiac and Cardiovascular Systems
Research subject
Natural Science, Medicine
Identifiers
URN: urn:nbn:se:lnu:diva-125007DOI: 10.1016/s0003-4975(02)04318-7OAI: oai:DiVA.org:lnu-125007DiVA, id: diva2:1801678
Available from: 2023-10-02 Created: 2023-10-02 Last updated: 2023-11-07Bibliographically approved

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Bergh, Cecilia

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