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Clinically significant macular edema in an underserved population: Association with demographic factors and hemoglobin A1c
Indiana University School of Optometry, USA.
Indiana University School of Optometry, USA;Aeon Imaging LLC, USA.
Indiana University School of Optometry, USA;Aeon Imaging LLC, USA.
Arizona State University, USA.
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2024 (English)In: Optometry and Vision Science, ISSN 1040-5488, E-ISSN 1538-9235, Vol. 101, no 1, p. 25-36Article in journal (Refereed) Published
Sustainable development
SDG 3: Ensure healthy lives and promote well-being for all at all ages
Abstract [en]

SIGNIFICANCE: Suspected clinically significant macular edema (SCSME) from exudates differed among ethnic groups in our underserved population. African American and Asian subjects had higher prevalence than Hispanics and non-Hispanic Caucasians, from the same clinics. Men had higher prevalence than women. Highly elevated blood glucose was frequent and associated with SCSME.

PURPOSE: We investigated the association between the presence of SCSME from exudates and hemoglobin A1c (HbA1c), as well as demographic factors such as age, sex, and ethnic group. Our population was underserved diabetic patients from the same geographic locations. Ethnic groups were White Hispanic, non-Hispanic Caucasian, African American, and Asian, with a high proportion of underrepresented minorities.

METHODS: In a diabetic retinopathy screening study at four community clinics in Alameda County, California, nonmydriatic 45° color fundus images were collected from underserved diabetic subjects following the EyePACS imaging protocol. Images were analyzed for SCSME from exudates by two certified graders. Logistic regression assessed the association between SCSME from exudates and age, sex, ethnic group, and HbA1c.

RESULTS: Of 1997 subjects, 147 (7.36%) had SCSME from exudates. The mean ± standard deviation age was 53.4 ± 10.5 years. The mean ± standard deviation HbA1c level was 8.26 ± 2.04. Logistic regression analysis indicated a significant association between presence of SCSME from exudates and HbA1c levels (p<0.001), sex (p=0.027), and ethnicity (p=0.030). African Americans (odds ratio [OR], 1.63; 95% confidence interval [CI], 1.06 to 2.50; p=0.025) and Asians (OR, 1.63; 95% CI, 1.05 to 2.54; p=0.029) had a higher risk than Hispanics. After adjusting for ethnicity, sex, and age, the odds of developing SCSME from exudates increased by 26.5% with every 1% increase in HbA1c level (OR, 1.26; 95% CI, 1.18 to 1.36; p<0.001).

CONCLUSIONS: In our underserved population, many diabetic patients had very high HbA1c values. Ethnic background (African American > Asians > Hispanics), sex (male > female), and HbA1c level were strong indicators for identifying who is at increased risk of developing SCSME from exudates.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2024. Vol. 101, no 1, p. 25-36
National Category
Ophthalmology
Research subject
Natural Science, Medicine; Natural Science, Optometry
Identifiers
URN: urn:nbn:se:lnu:diva-127788DOI: 10.1097/OPX.0000000000002096ISI: 001162963000008PubMedID: 38350055Scopus ID: 2-s2.0-85185000609OAI: oai:DiVA.org:lnu-127788DiVA, id: diva2:1838048
Available from: 2024-02-15 Created: 2024-02-15 Last updated: 2025-02-07Bibliographically approved

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Baskaran, Karthikeyan

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