This article examines the Indies' significant role in Spain's economic warfare during Philip IV's reign. It challenges the perception of the American territories as peripheral participants, emphasizing their central involvement in the General Reprisal against the French during the Franco-Spanish War. The study reveals interconnected policies between the Indies and European territories, the adaptations of the reprisal scheme to suit the American settings, and the consideration of each territory's unique conditions. It also highlights the importance of the French mercantile community in Seville, their integration into the Atlantic trade, and their strategies to recover property in the American territories. Additionally, the article analyzes the introduction of rogation days in the Indies as a complementary measure, serving as a propaganda tool to otherize the French, influence public opinion, and shape perceptions of foreignness. Overall, the research enhances our understanding of Spain's economic warfare strategies and their global impact.