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Replicase Gene of Coxsackievirus B3
University of Kalmar, School of Pure and Applied Natural Sciences.ORCID iD: 0000-0003-3841-4826
1984 (English)In: Journal of Virology, ISSN 0022-538X, E-ISSN 1098-5514, Vol. 51, no 3, p. 742-746Article in journal (Refereed) Published
Abstract [en]

A cDNA copy covering two-thirds of the coxsackievirus B3 genomewas cloned in the PstI site of the pBR322 vector. A nucleotidesequence containing the gene for the viral replicase and the3' noncoding region of the coxsackievirus B3 genome was determined.The predicted amino acid sequence of the coxsackievirus B3 replicasewas shown to be remarkably similar to that of the poliovirus1 replicase. The 3' noncoding region, in contrast, was onlyweakly homologous to the poliovirus 1 sequence but showed aclose relationship to the sequence of swine vesicular diseasevirus, a variant of coxsackievirus B5. A 13-nucleotide-longsegment located near the polyadenylic acid junction is conservedin several members of the enterovirus group and may thus servean important function during replication of viral RNA. 

Place, publisher, year, edition, pages
1984. Vol. 51, no 3, p. 742-746
National Category
Microbiology in the medical area Microbiology in the medical area
Research subject
Biomedical Sciences, Virology; Natural Science, Microbiology
Identifiers
URN: urn:nbn:se:lnu:diva-541OAI: oai:DiVA.org:lnu-541DiVA, id: diva2:307271
Available from: 2010-04-01 Created: 2010-04-01 Last updated: 2018-01-12Bibliographically approved

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Lindberg, A Michael

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