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Continuous Production of Somatomedin C with Immobilized Transformed Yeast Cells
Institute of Biotechnology, Swiss Federal Institute of Technology, Hönggerberg, CH-8093 Zfirich, Switzerland.ORCID iD: 0000-0001-8899-5046
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1988 (English)In: Applied Microbiology and Biotechnology, ISSN 0175-7598, E-ISSN 1432-0614, Vol. 28, no 3, p. 215-221Article in journal (Refereed) Published
Abstract [en]

Yeast cells producing the growth hormonesomatomedin C (SMC) were constructedand applied in the immobilized form continuouslyfor a period of over 10 days in a flowthroughbioreactor. The construction of theMF~I-SMC fusion vector p336/l is given as wellas the results of the influence of various nutrientseffecting hormone production. Immobilization ofthe transformed yeast cells is described and theirapplication in a continuous bioreactor system.This study demonstrates the feasibility of a longtermand high-level hormone production by immobilizedtransformed yeast. The SMC productivitiesof free cells in batch and immobilized cellsunder continuous conditions were 0.2--0.3 and0.5--0.6 mg per g wet cells and day, respectively. 

Place, publisher, year, edition, pages
1988. Vol. 28, no 3, p. 215-221
National Category
Biochemistry and Molecular Biology
Research subject
Natural Science, Biochemistry
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URN: urn:nbn:se:lnu:diva-600DOI: 10.1007/BF00250444OAI: oai:DiVA.org:lnu-600DiVA, id: diva2:307330
Available from: 2010-04-01 Created: 2010-04-01 Last updated: 2017-12-12Bibliographically approved

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Brodelius, Peter

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