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Effects of amrinone on the electromechanical coupling in frog skeletal muscle fibres
Department of Pharmacology, University of Lund.ORCID iD: 0000-0002-5889-7792
1990 (English)In: Acta Physiologica Scandinavica, ISSN 0001-6772, E-ISSN 1365-201X, Vol. 139, p. 289-295Article in journal (Refereed) Published
Abstract [en]

The contractile effects of I.I mM amrinone were studied on isolated skeletal muscle fibres of the frog (2–5 °C, slack length). Amrinone potentiated the twitch amplitude and the maximum tetanic tension and also enhanced the maximum contracture response elicited by 117.5 mM K+ (mean increase 6.3 ± 1.8 %, n = 6, P < 0.02). The time to halfrelaxation of the potassium contracture was slightly increased (mean change 13.8 ± 3.5%, n = 7, P < 0.01). Amrinone furthermore shifted the S-shaped curve relating contracture tension to log K+ to the left, and thus reduced the threshold depolarization (the mechanical threshold needed) to elicit a contracture (mean reduction 11 ± 1 mV). The duration of the action potential at the –25 mV level was slightly increased by amrinone, whereas the resting membrane potential was unaffected. 

Place, publisher, year, edition, pages
1990. Vol. 139, p. 289-295
National Category
Medical and Health Sciences
Research subject
Natural Science, Biomedical Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-926DOI: 10.1111/j.1748-1716.1990.tb08926.xOAI: oai:DiVA.org:lnu-926DiVA, id: diva2:307709
Available from: 2010-04-01 Created: 2010-04-01 Last updated: 2017-12-12Bibliographically approved

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Månsson, Alf

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