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Effects of amrinone on the contractile behaviour of frog striated muscle fibres
Department of Pharmacology, University of Lund, Sweden.ORCID iD: 0000-0002-5889-7792
Department of Pharmacology, University of Lund, Sweden.
1985 (English)In: Acta Physiologica Scandinavica, ISSN 0001-6772, E-ISSN 1365-201X, Vol. 125, no 3, p. 481-493Article in journal (Refereed) Published
Abstract [en]

The effects of amrinone (0.005–2.1 mM) were studied on isolated single muscle fibres of the frog (0.6–4.3 °C). In the concentrations used amrinone potentiated the isometric twitch, increased the initial rate of force development and prolonged the time to peak twitch force and the time from peak force to half relaxation. There was a moderate but statistically significant (P < 0.001) enhancement of the maximum tetanic force and a marked slowing of the relaxation phase of the tetanus. Amrinone depressed the velocity of unloaded shortening by 33 ± 2% (mean ± SE, π= 6) and reduced the curvature of the force-velocity relation leading to an increase of a/PO in Hill's (1938) hyperbolic equation. In accordance with the effects of amrinone on the force–velocity relation, there was a decrease in the rate of redevelopment of force after the fibre was released to zero tension during the tetanus plateau. The evidence suggests that the drug affects the contractile properties of frog muscle fibres by two different mechanisms: (1) amrinone affects the excitation–contraction coupling causing enhanced calcium release in response to membrane excitation and (2) amrinone exerts a direct effect on the kinetics of turnover of the myosin cross-bridges. The latter aspect of the drug effect was evaluated in terms of A. F. Huxley's (1957) cross-bridge model by means of a computer program. 

Place, publisher, year, edition, pages
1985. Vol. 125, no 3, p. 481-493
National Category
Medical and Health Sciences
Research subject
Natural Science, Biomedical Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-930DOI: 10.1111/j.1748-1716.1985.tb07745.xOAI: oai:DiVA.org:lnu-930DiVA, id: diva2:307713
Available from: 2010-04-01 Created: 2010-04-01 Last updated: 2017-12-12Bibliographically approved

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Månsson, Alf

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