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Defective Fc receptor-mediated clearance in patients with primary biliary cirrhosis
Department of Clinical Immunology and Transfusion Medicine, University Hospital, Uppsala.ORCID iD: 0000-0001-7888-1571
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1991 (English)In: Gastroenterology, ISSN 0016-5085, E-ISSN 1528-0012, Vol. 101, no 4, p. 1076-1082Article in journal (Refereed) Published
Abstract [en]

Fc receptor-mediated clearance of immunoglobulin G-coated autologous erythrocytes was studied in patients with primary biliary cirrhosis (n = 14), alcoholic liver cirrhosis (n = 5) and healthy reference individuals (n = 14). The mean half-life of the sensitized erythrocytes was significantly prolonged in patients with primary biliary cirrhosis (85 +/- 25 minutes; P less than 0.001) compared with the corresponding value in patients with alcoholic cirrhosis (16 +/- 2 minutes) and healthy reference individuals (20 +/- 5 minutes), respectively. No correlation between clearance rate and age, liver histopathology, or serum levels of bilirubin, aminotransferases, immunoglobulin G, immunoglobulin A, and Clq binding or C3-containing immune complexes was found. The results presented here indicate a profound disturbance of Fc receptor-mediated immune clearance function in patients with primary biliary cirrhosis. 

Place, publisher, year, edition, pages
1991. Vol. 101, no 4, p. 1076-1082
National Category
Immunology in the medical area
Research subject
Biomedical Sciences, Immunology
Identifiers
URN: urn:nbn:se:lnu:diva-1117OAI: oai:DiVA.org:lnu-1117DiVA, id: diva2:307906
Available from: 2010-04-01 Created: 2010-04-01 Last updated: 2018-01-12Bibliographically approved

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Nilsson Ekdahl, Kristina

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