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Flow-force relationships during energy transfer between mitochondrial proton pumps
2Howard Hughes Medical Institute Research Laboratories, Molecular Biology Institute, University of California, Los Angeles, CA (U.S.A.).
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1991 (English)In: Biochimica et Biophysica Acta - Bioenergetics, ISSN 0005-2728, E-ISSN 1879-2650, Vol. 1058, no 2, p. 297-303Article in journal (Refereed) Published
Abstract [en]

The effect of inhibitors of proton pumps, of uncouplers and of permeant ions on the relationship between input force, , and output flows of the ATPase, redox and transhydrogenase H+-pumps in submitochondrial particles was investigated. It is concluded that: (1) The decrease of output flow of the transhydrogenase proton pump, defined as the rate of reduction of NADP+ by NADH, is linearily correlated with the decrease of input force, , in an extended range of , independently of whether the H+-generating pump is the ATPase or a redox pump, or whether is depressed by inhibitors of the H+-generating pump such as oligomycin or malonate, or by uncouplers. (2) The output flows of the ATPase and of the site I redox H+-pumps exhibit a steep dependence on . The flow-force relationships differ depending on whether the depression of is induced by inhibitors of the H+-generating pump, by uncouplers or by lipophilic anions. (3) With the ATPase as H+-consuming pump, at equivalent values, the output flow is more markedly inhibited by malonate than by uncouplers; the latter, however, are more inhibitory than lipophilic anions such as ClO4−. With redox site I as proton-consuming pump, at equivalent values, the output flow is more markedly inhibited by oligomycin than by uncouplers; again, uncouplers are more inhibitory than ClO4−. (4) The results provide further support for a delocalized interaction of transhydrogenase with other H+-pumps. 

Place, publisher, year, edition, pages
1991. Vol. 1058, no 2, p. 297-303
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Biochemistry and Molecular Biology
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Chemistry, Biochemistry
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URN: urn:nbn:se:lnu:diva-1176DOI: 10.1016/S0005-2728(05)80250-6OAI: oai:DiVA.org:lnu-1176DiVA, id: diva2:307965
Available from: 2010-04-01 Created: 2010-04-01 Last updated: 2017-12-12Bibliographically approved

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Persson, Bengt L.

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