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Phospholipase C from Clostridium perfringens stimulates formation of platelet-activating factor (PAF-acether) in cultured intestinal epithelial cells (INT 407)
Clinical Research Center, Linköping University .
1991 (English)In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, E-ISSN 1502-7708, Vol. 26, no 10, p. 1000-1006Article in journal (Refereed) Published
Abstract [en]

This study demonstrates the ability of phospholipase C from Clostridium perfringens to stimulate the generation of platelet-activating factor (PAF-acether) in cultured intestinal epithelial cells (INT 407). Cells were exposed to phospholipase C for up to 60 min, and the content of PAF-acether within the cells and in the extracellular medium was determined. Phospholipase C caused a time-dependent formation of PAF-acether within the cells and also release of PAF-acether to the medium. In contrast, phospholipase C did not affect the cellular acetylhydrolase activity or the ability of the cells to metabolize extracellularly added C-14-PAF-acether. These findings suggest the possibility that intestinal epithelial cells, when stimulated with a naturally occurring intestinal bacterial toxin, generate and release PAF-acether. The possibility that this might contribute to the pathophysiology of inflammatory bowel disease is discussed. 

Place, publisher, year, edition, pages
1991. Vol. 26, no 10, p. 1000-1006
National Category
Medical and Health Sciences
Research subject
Natural Science, Biomedical Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-1727DOI: 10.3109/00365529109003948OAI: oai:DiVA.org:lnu-1727DiVA, id: diva2:308775
Available from: 2010-04-06 Created: 2010-04-06 Last updated: 2017-12-12Bibliographically approved

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Gustafson-Svärd, Christina

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