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The conditioned avoidance response test re-evaluated: Is it a sensitive test also for the detection of potentially atypical antipsychotics?
Department of Psychiatry, Scott & White Clinic, Temple, TX 75608, USA..ORCID iD: 0000-0003-1806-307X
1999 (English)In: Neurosci and Biobehav Reviews, Vol. 23, no 6, p. 851-862Article, review/survey (Other academic) Published
Abstract [en]

The present review discusses the history and paradigm of the conditioned avoidance response (CAR) in rats for the detection of potential antipsychotic activity of drugs. In addition, the role of dopamine (DA) D2, serotonin (5-HT)2A/2C, alpha1, 5-HT1A, DA D4, muscarinic and glutamate receptors in the suppression of CAR induced by various classes of drugs is evaluated. Finally, data investigating brain sites of action for the mediation of CAR behavior is discussed. It is concluded that the CAR test, originally found to be sensitive for the detection of antipsychotic drugs with high affinity as antagonists for brain dopamine receptors, is also sensitive for the detection of potentially antipsychotic compounds acting primarily via neurotransmitter receptors other than the DA D2 receptor. Furthermore, the review confirms the importance of the nucleus accumbens(shell) in the mediation of effects on CAR produced by traditional, as well as atypical antipsychotic drugs.

Place, publisher, year, edition, pages
1999. Vol. 23, no 6, p. 851-862
National Category
Pharmacology and Toxicology
Research subject
Biomedical Sciences, Pharmacology
Identifiers
URN: urn:nbn:se:lnu:diva-5086PubMedID: 10541060OAI: oai:DiVA.org:lnu-5086DiVA, id: diva2:315067
Available from: 2010-04-28 Created: 2010-04-28 Last updated: 2018-01-12Bibliographically approved

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Wadenberg, Marie-Louise

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