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Serotonergic mechanisms in neuroleptic-induced catalepsy in the rat.
UNIV STOCKHOLM, DEPT PSYCHOL, S-10691 STOCKHOLM, SWEDEN.ORCID iD: 0000-0003-1806-307X
1996 (English)In: Neurosci and Biobehav Reviews, Vol. 20, p. 325-339Article, review/survey (Other academic) Published
Abstract [en]

The present paper reviews a series of experiments aimed at elucidating the interaction between specific dopamine (DA) and 5-hydroxytryptamine (5-HT) receptors in the mediation of extrapyramidal motor functions in the rat. There is strong evidence to suggest that (1) the catalepsy produced by dopamine D-1 or D-2 receptor antagonists can be completely antagonized by the administration of 5-HT1A receptor agonists acting at 5-HT autoreceptors in the median raphe nucleus; (2) the catalepsy produced by a dopamine D-2 receptor antagonist can be completely antagonized by treatment with a 5-HT2A/C receptor agonist; and (3) the catalepsy produced by blockade of either dopamine D-1 or D-2 receptors is not affected by the administration of a 5-HT2A/C receptor antagonist. The emerging picture of DA/5-HT receptor interactions in the mediation of extrapyramidal motor functions is of great interest in relation to present efforts to develop new atypical neuroleptics with affinity for brain 5-HT receptor subtypes, and also for the observations that new serotonin selective re-uptake inhibiting antidepressants can produce parkinson-like symptoms in vulnerable individuals.

Place, publisher, year, edition, pages
1996. Vol. 20, p. 325-339
National Category
Pharmacology and Toxicology
Research subject
Biomedical Sciences, Pharmacology
Identifiers
URN: urn:nbn:se:lnu:diva-5088OAI: oai:DiVA.org:lnu-5088DiVA, id: diva2:315069
Available from: 2010-04-28 Created: 2010-04-28 Last updated: 2018-01-12Bibliographically approved

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Wadenberg, Marie-Louise

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