lnu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Immune complex-mediated cytokine production is regulated by classical complement activation both in vivo and in vitro
Uppsala Univ, Unit Clin Immunol, Uppsala, Sweden.
Uppsala Univ, Unit Clin Immunol, Uppsala, Sweden.
Uppsala Univ, Unit Clin Immunol, Uppsala, Sweden.
Uppsala Univ, Unit Clin Immunol, Uppsala, Sweden.ORCID iD: 0000-0001-7888-1571
Show others and affiliations
2008 (English)In: Advances in experimental medicine and biology, Vol. 632, p. 187-201Article, review/survey (Other academic) Published
Abstract [en]

Immune complexes (IC) induce a number of cellular functions, including the enhancement of cytokine production from monocytes, macrophages and plasmacytoid dendritic cells. The range and the composition of cytokines induced by IC in vitro is influenced by the availability of an intact classical complement cascade during cell Culture, as we have showed in our studies on artificial IC and on cryoglobulins purified from patients with lymphoproliferative diseases. When IC purified from systemic lupus erythematosus sera were used to stimulate in vitro cytokine production, the amount of circulating IC and IC-induced cytokine levels depended both on in vivo classical complement function as well as on the occurrence of anti-SSA, but not on anti-dsDNA or any other autoantibodies. Collectively these findings illustrate that studies on IC-induced cytokine production in vitro requires stringent cell culture conditions with complete control and definition of access to an intact classical complement pathway in the cell cultures. If IC are formed in vivo, the results have to be interpreted in the context of classical complement activation in vivo as well as the occurrence of IC-associated autoantibodies at the time of serum sampling.

Place, publisher, year, edition, pages
2008. Vol. 632, p. 187-201
National Category
Immunology in the medical area
Research subject
Biomedical Sciences, Immunology
Identifiers
URN: urn:nbn:se:lnu:diva-5104DOI: 10.1007/978-0-387-78952-1_14OAI: oai:DiVA.org:lnu-5104DiVA, id: diva2:315085
Note

4th Aegean Workshop on Complement Associated Diseases, Animal Models and Therapeutics Porto Heli, GREECE, JUN 10-17, 2007

Available from: 2010-04-28 Created: 2010-04-28 Last updated: 2018-01-12Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full text

Authority records BETA

Nilsson Ekdahl, Kristina

Search in DiVA

By author/editor
Nilsson Ekdahl, Kristina
Immunology in the medical area

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 85 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf