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Towards Phage Display-Derived Synthetic Receptors for Adenine
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (BBCL)
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (BBCL)
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (BBCL)ORCID iD: 0000-0002-0407-6542
2010 (English)Conference paper, (Refereed)
Abstract [en]

The expression of peptides on phage coat proteins via genetic engineering was first achieved in 1985 [1] and was followed by the construction of phage display combinatorial libraries in 1990 [2].  Phage display combinatorial libraries have been used not only to find peptides that interact with various biomolecules such as receptors, antibodies, enzyme active sites, and protein surfaces, but also to find peptides with affinity for metals and plastics and with function in non-biological environments [3].

In this study, we have challenged a cyclic heptamer phage display library with surfaces adenine functionalised surfaces with the aim of identifying peptide motifs selective for adenine. The synthesis and characterisation of surfaces, and results from phage display screening shall be presented.

 

 

[1] Smith, G.P. Science (1985) 228, 1315-1317.

[2] Scott, J.K.; Smith, G.P. Science (1990) 249, 386-390.

[3] Olofsson, L.; Söderberg, P.; Ankarloo, J.; Nicholls, I.A. J. Mol. Recognit. (2008) 19, 18-25.

Place, publisher, year, edition, pages
2010.
National Category
Organic Chemistry
Research subject
Natural Science, Organic Chemistry
Identifiers
URN: urn:nbn:se:lnu:diva-6714OAI: oai:DiVA.org:lnu-6714DiVA: diva2:329019
Conference
22:nd Organic Chemistry Days (Organikerdagarna), Uppsala
Available from: 2010-07-07 Created: 2010-07-07 Last updated: 2015-04-16Bibliographically approved

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Citation style
  • apa
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