lnu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Towards Synthetic Neuraminidases
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (BBCL)
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (BBCL)
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (BBCL)ORCID iD: 0000-0002-7392-0591
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (BBCL)
Show others and affiliations
2010 (English)Conference paper, (Refereed)
Abstract [en]

Influenza endemics and pandemics have been a menace to humanity through the ages and pose ominous threats and with dire consequences for humanity [1]. A better understanding of the virus, the epidemiology of the disease, and its structure and function is essential for creating new therapies and even for better understanding resistance to existing treatments. At the molecular level the two capside proteins Neuraminidase and Hemagglutinin are engaged in interactions with host cell surface sialic acid residues, and are critical for contagion and budding off of the virus into and from the cell, and have been the  targets for drug development strategies [2]. The rise of strains of the virus resistant to drugs targeting Neuraminidase make it crucial to develop techniques for better understanding of the virus and hence design of better antiviral agents [3].

In this study a combination of molecular dynamics (MD) and NMR spectroscopy [4-7] is been utilised in order to screen some 60 polymers for candidate systems [8] for use in the preparation of synthetic polymer neauraminidase mimics.  Progress in the design, synthesis and evaluation of these materials shall be presented.

References

1. Webster et al., Microbiol. Rev., 56, 152-175 (1992).

2. von Itzstein et al., Nature, 263, 418-423 (1993).

3. Lindberg et al., Chemosphere, 57, 1479-1488. (2004).

4. Svensson et al., J. Chromatogr. A, 1024, 39-44 (2004).

5. O’Mahony et al., Analyst, 23, 1147-1115 (2007).

6. Karlsson et al., J. Am. Chem. Soc., 131, 13297-13304 (2009).

7. Nicholls et al., Biosens. Bioelectron., 25, 553-557 (2009).

8. Shoravi et al., unpublished results (2010).

 

Place, publisher, year, edition, pages
2010.
National Category
Organic Chemistry
Research subject
Natural Science, Organic Chemistry
Identifiers
URN: urn:nbn:se:lnu:diva-6715OAI: oai:DiVA.org:lnu-6715DiVA: diva2:329020
Conference
22:nd Organic Chemistry Days (Organikerdagarna), Uppsala
Available from: 2010-07-07 Created: 2010-07-07 Last updated: 2016-11-11Bibliographically approved

Open Access in DiVA

No full text

Search in DiVA

By author/editor
Shoravi, SiamakOrozovic, KanitaKarlsson, Björn C. G.Wiklander, Jesper G.Nicholls, Ian A.
By organisation
School of Natural Sciences
Organic Chemistry

Search outside of DiVA

GoogleGoogle Scholar

Total: 99 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf