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A synthetic polymer with avidin-like binding properties
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (BBCL)
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (BB)ORCID iD: 0000-0002-7392-0591
Attana AB, Stockholm.
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (BBCL)ORCID iD: 0000-0002-0407-6542
2010 (English)Conference paper, (Refereed)
Abstract [en]

A series of streptavidin mimicking molecularly imprinted polymers has been developed and evaluated for their biotin binding characteristics. A combination of molecular dynamics and NMR spectroscopy was used to examine potential polymer systems, in particular with the functional monomers methacrylic acid and 2-acrylamidopyridine. Synthesis of co-polymers of ethylene dimethacrylate and one or both of these functional monomers was performed. A combination of radioligand binding studies and surface area analyses (BET, SEM) demonstrated the presence of selectivity in polymers prepared using methacrylic acid as functional monomer. This correlated well with the molecular dynamics studies, showing the power of this methodology as a prognostic tool for predicting the behaviour of molecularly imprinted polymers.

Place, publisher, year, edition, pages
2010.
National Category
Organic Chemistry
Research subject
Natural Science, Organic Chemistry
Identifiers
URN: urn:nbn:se:lnu:diva-6728OAI: oai:DiVA.org:lnu-6728DiVA: diva2:329052
Conference
MIP2010: The 6th International Conference on Molecular Imprinting, New Orleans
Available from: 2010-07-07 Created: 2010-07-07 Last updated: 2016-11-11Bibliographically approved

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Wiklander, Jesper G.Karlsson, Björn C. G.Nicholls, Ian A.
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