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Significant Impact on Muscle Mechanics of Small Non-linearities in Myofilament Elasticity
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (Bionanogroup)ORCID iD: 0000-0002-5889-7792
2010 (English)In: Biophysical Journal, ISSN 0006-3495, E-ISSN 1542-0086, Vol. 99, no 6, p. 1869-1875Article in journal (Refereed) Published
Abstract [en]

Important mechanisms in muscle contraction have recently been re-evaluated on basis of analyses that rely on the assumption of linear myofilament elasticity. However, the present theoretical study shows that non-linearity of this elasticity, even when so minor that it may be difficult to detect in experimental data, could have great impact on the interpretation of muscle mechanical experiments. This is illustrated using simulated stiffness and strain vs force data for muscle fibers shortening at different constant velocities. There is substantial quantitative agreement, for this condition, between models with distributed myofilament compliance and models where the compliance of the myofilaments and the actomyosin cross-bridges are lumped together into two separate elastic elements acting in series. The data thus support the usefulness of the latter, simpler, type of model in the analysis. However, most importantly, the data emphasize the importance of caution before re-evaluating fundamental mechanisms of muscle contraction based on analyses relying on the assumption of linear myofilament elasticity.

Place, publisher, year, edition, pages
Elsevier , 2010. Vol. 99, no 6, p. 1869-1875
National Category
Physiology
Research subject
Natural Science, Biomedical Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-7218DOI: 10.1016/j.bpj.2010.07.029Scopus ID: 2-s2.0-77957339262OAI: oai:DiVA.org:lnu-7218DiVA, id: diva2:343515
Available from: 2010-08-13 Created: 2010-08-13 Last updated: 2018-01-12Bibliographically approved

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Månsson, Alf

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