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Actomyosin-ADP states, interhead cooperativity, and the force-velocity relation of skeletal muscle.
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (Bionanogroup)ORCID iD: 0000-0002-5889-7792
2010 (English)In: Biophysical Journal, ISSN 0006-3495, E-ISSN 1542-0086, Vol. 98, no 7, 1237-1246 p.Article in journal (Refereed) Published
Abstract [en]

Despite intense efforts to elucidate the molecular mechanisms that determine the maximum shortening velocity and the shape of the force-velocity relationship in striated muscle, our understanding of these mechanisms remains incomplete. Here, this issue is addressed by means of a four-state cross-bridge model with significant explanatory power for both shortening and lengthening contractions. Exploration of the parameter space of the model suggests that an actomyosin-ADP state (AM( *)ADP) that is separated from the actual ADP release step by a strain-dependent isomerization is important for determining both the maximum shortening velocity and the shape of the force-velocity relationship. The model requires a velocity-dependent, cross-bridge attachment rate to account for certain experimental findings. Of interest, the velocity dependence for shortening contraction is similar to that for population of the AM( *)ADP state (with a velocity-independent attachment rate). This accords with the idea that attached myosin heads in the AM( *)ADP state position the partner heads for rapid attachment to the next site along actin, corresponding to the apparent increase in attachment rate in the model.

Place, publisher, year, edition, pages
2010. Vol. 98, no 7, 1237-1246 p.
National Category
Biophysics
Research subject
Natural Science, Biomedical Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-7221DOI: 10.1016/j.bpj.2009.12.4285PubMedID: 20371323OAI: oai:DiVA.org:lnu-7221DiVA: diva2:343516
Available from: 2010-08-13 Created: 2010-08-13 Last updated: 2017-03-23Bibliographically approved

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CiteExportLink to record
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Cite
Citation style
  • apa
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  • modern-language-association-8th-edition
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More styles
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  • Other locale
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