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Detection of nodularin in European flounder (Platichthys flesus) in the west coast of Sweden: evidence of nodularin mediated oxidative stress
University of Kalmar, School of Pure and Applied Natural Sciences. (Marine Ecology)
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (Marine Ecology)ORCID iD: 0000-0001-7155-3604
Toxicon, Sweden.
2009 (English)In: Harmful Algae, ISSN 1568-9883, E-ISSN 1878-1470, Vol. 8, no 6, p. 832-838Article in journal (Refereed) Published
Abstract [en]

The brackish, bloom-forming cyanobacterium Nodularia spumigena produces a peptide called nodularin, which may induce liver damage in fish. In the summer of 2007, nodularin was detected in liver tissue of European flounder caught in Swedish waters of Öresund, within the upper salinity limit for N. spumigena. Nodularinconcentrations ranging between 22 and 557 μg kg−1 liver (d.w.) were detected in fish liver. Nodularin was not detected in blue mussels (Mytilus edulis). Although N. spumigena blooms can occur in the area, the cyanobacteria were only present in very small amounts in 2007. Results suggested that nodularin accumulated inflounder livers during the summer of 2006, when vast N. spumigena blooms were observed in Öresund, and persisted over several months. Nodularin has previously been shown to induce oxidative stress in mice, crustaceans and mollusks but work on the potential negative effects of nodularin on fish is still scarce. To examine the dynamics of nodularin induced oxidative stress in liver tissue of flounder, the differential responses of the antioxidant enzymes glutathione-S-transferase catalase(CAT) and the formation of malondialdehyde (MDA) were monitored during 14 days in flounder exposed to an intraperitoneal injection of nodularin (0, 2, 10 and 50 μg nodularin kg−1 body weight). The activities of GST and CAT in the liver decreased significantly in the 50 μg nodularin kg−1 exposure after 7 days, but were restored to control levels after an additional 10 days of recovery. The results suggested that nodularin induced oxidative stress in terms of decreased GST and CATactivity, which can result in increased vulnerability of the cell to reactive oxygen species (ROS). No significant changes could be found in MDA levels between the treatments. Thus, the antioxidant defense system presumably managed to prevent oxygen mediated toxicity as seen by the unchanged levels of MDA. Alteration of the enzymatic defense system may increase energetic costs, thus reducing fish growth and survival. The present study also suggests that oxidative stress biomarkers can be used in fish to detect early responses to nodularin.

Place, publisher, year, edition, pages
Elsevier , 2009. Vol. 8, no 6, p. 832-838
Keywords [en]
Flounder, Baltic Sea, cyanobacteria, nodularin, oxidative stress
National Category
Ecology
Research subject
Natural Science, Aquatic Ecology
Identifiers
URN: urn:nbn:se:lnu:diva-7341DOI: 10.1016/j.hal.2009.03.003OAI: oai:DiVA.org:lnu-7341DiVA, id: diva2:343830
Projects
Impact of harmful cyanobacteria of coastal fish recruitment in the Baltic Sea, FormasAvailable from: 2010-08-16 Created: 2010-08-16 Last updated: 2017-12-12Bibliographically approved
In thesis
1. Influence of cyanobacterial blooms on coastal fish recruitment
Open this publication in new window or tab >>Influence of cyanobacterial blooms on coastal fish recruitment
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Cyanobacteria are the oldest oxygen-producing organisms on Earth and can be found in almost every terrestrial and aquatic habitat. Their long evolutionary history has enabled them to develop diverse adaptations in order to increase their survival in environments subjected to natural and anthropogenic changes. The frequency and intensity of cyanobacterial blooms in the Baltic Sea have increased during the last century. Summer blooms consisting of the filamentous cyanobacterial genera Nodularia, Aphanizomenon and Anabaena may cover up to 50 % of the Baltic Sea surface, which are the largest cyanobacterial blooms in the world. Simultaneously, recruitment of spring spawning fish such as perch (Perca fluviatilis) and pike (Esox Lucius) have decreased along the Baltic Sea coast. Temporal variations in adult fish abundance have been linked to recruitment success, which is dependent on growth of juvenile fish. Generally, low growth rates affect survival of juvenile fish by causing an increase in the time spent in stages prone to predation and by increasing winter mortality which is negatively size selective. Since growth is a crucial factor determining fish recruitment, all parameters that have the potential to influence fish growth could affect fish recruitment dynamics. Cyanobacteria negatively influence fish growth directly (toxicity, turbidity and changes in water quality) and indirectly (toxin transfer, changes in zooplankton community structure). Cyanobacterial toxins i.e. nodularin accumulate in common coastal fish species (flounders, perch and roach) resulting in an energetic cost associated with detoxification. Cyanobacteria, toxic or non-toxic, also affect the behavior of fish (prey capture) further increasing energetic costs. In nature, spatial variations of both cyanobacteria and salinity are a deadly combination for juvenile fish leading to increased detrimental effects of cyanobacteria on juvenile fish in brackish waters compared to freshwater. However, different fish populations react differently to cyanobacteria i.e. a marine population had higher tolerance to cyanobacteria compared to an oligotrophic population. At the coastal ecosystem level, cyanobacteria cannot explain the decline of juvenile fish. Nevertheless, at the local scale cyanobacteria certainly influence the recruitment of juvenile fish.  

Place, publisher, year, edition, pages
Växjö: Linnaeus University Press, 2013
Series
Linnaeus University Dissertations ; 121/2013
Keywords
Cyanobacteria, coastal fish recruitment
National Category
Ecology
Research subject
Natural Science, Aquatic Ecology
Identifiers
urn:nbn:se:lnu:diva-24684 (URN)978-91-87427-11-4 (ISBN)
Public defence
2013-03-22, Fullriggaren, Landgången 4, Kalmar, 09:00 (English)
Opponent
Supervisors
Funder
Formas, 217-2007-530
Available from: 2013-03-11 Created: 2013-03-06 Last updated: 2014-02-25Bibliographically approved

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Persson, Karl-JohanLegrand, Catherine

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