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Acute lymphoblastic leukemia cells that survive combination chemotherapy in vivo remain sensitive to allogeneic immune effects
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. University of Rochester, USA.
University of Rochester, USA.
University of Rochester, USA.
University of Rochester, USA.
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2011 (English)In: Leukemia research: a Forum for Studies on Leukemia and Normal Hemopoiesis, ISSN 0145-2126, E-ISSN 1873-5835, Vol. 35, no 6, p. 800-807Article in journal (Refereed) Published
Abstract [en]

Allogeneic hematopoietic stem cell transplantation is often performed for patients with acute lymphoblastic leukemia (ALL) whose disease has relapsed after chemotherapy treatment. However, graft versus leukemia (GVL) effects in ALL are generally weak and the mechanisms of this weakness are unknown. These studies tested the hypothesis that ALL cells that have survived conventional chemotherapy in vivo acquire relative resistance to the allogeneic GVL effect. C57BL/6 mice were injected with murine pre-B ALL lines driven by human mutations and then were treated with combination chemotherapy. ALL cells surviving therapy were analysed in vitro and in vivo for acquisition of resistance to chemotherapy, radiation, cytolytic T cells, NK cells, LAK cells and cytokines. In vivo drug treatment did lead to leukemia population with more rapid proliferation and also decreased sensitivity to vincristine, doxorubicin and radiation. However, drug treatment did not produce ALL populations that were less sensitive to GVL effects in vitro or in vivo.

Place, publisher, year, edition, pages
2011. Vol. 35, no 6, p. 800-807
Keywords [en]
Graft versus leukemia effect, Allogeneic hematopoietic stem cell transplantation, Acute lymphoblastic leukemia, Chemotherapy, Cancer immunology, Graft versus host disease
National Category
Microbiology in the medical area
Research subject
Natural Science, Biomedical Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-9919DOI: 10.1016/j.leukres.2010.10.018PubMedID: 21074852OAI: oai:DiVA.org:lnu-9919DiVA, id: diva2:384509
Available from: 2011-01-10 Created: 2011-01-10 Last updated: 2018-01-12Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • ieee
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  • Other style
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