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Evidence of B Cell Immune Responses to Acute Lymphoblastic Leukemia in Murine Allogeneic Hematopoietic Stem Cell Transplantation Recipients Treated with Donor Lymphocyte Infusion and/or Vaccination
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. Univ Rochester, Med Ctr, Dept Pediat, Rochester, NY 14642 USA.
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2010 (English)In: Biology of blood and marrow transplantation, ISSN 1083-8791, E-ISSN 1523-6536, Vol. 17, no 2, p. 226-238Article in journal (Refereed) Published
Abstract [en]

These experiments explored mechanisms of control of acute lymphoblastic leukemia following allogeneic hematopoietic stem cell transplantation using a murine model of MHC-matched, minor histocompatibility antigen mismatched transplantation. The central hypothesis examined was that addition of active vaccination against leukemia cells would substantially increase the effectiveness of allogeneic donor lymphocyte infusion against ALL present in the host after transplant. While vaccination did increase the magnitude of type I T cell responses against leukemia cells associated with donor lymphocyte infusion, it did not lead to substantial improvement in long term survival. Analysis of immunological mechanisms of leukemia progression demonstrated that the failure of vaccination was not due to antigen loss in leukemia cells. However, analysis of survival provided surprising findings that, in addition to very modest type I T cell responses, a B cell response that produced antibodies that bind leukemia cells was found in long term survivors. The risk of death from leukemia was significantly lower in recipients that had higher levels of such antibodies. These studies raise the hypothesis that stimulation of B cell responses after transplant may provide a novel way to enhance allogeneic graft versus leukemia effects associated with transplantation.

Place, publisher, year, edition, pages
2010. Vol. 17, no 2, p. 226-238
National Category
Medical and Health Sciences
Research subject
Natural Science, Biomedical Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-9920DOI: 10.1016/j.bbmt.2010.08.021ISI: 000287350400007PubMedID: 20831897OAI: oai:DiVA.org:lnu-9920DiVA, id: diva2:384525
Available from: 2011-01-10 Created: 2011-01-10 Last updated: 2017-12-11Bibliographically approved

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