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Toll-like receptors (TLRs) and mannan-binding lectin (MBL): On constant alert in a hostile environment
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
2011 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 116, no 2, p. 90-99Article, review/survey (Refereed) Published
Abstract [en]

In the beginning were neither B cells nor T cells nor antibodies, but innate immune defense alone. The primary functional theme of innate immunity is the distinction between self and non-self, which is maintained by a vast number of cellular and subcellular components. In this context, the immense importance of the Toll-like receptors (TLRs) is well established. Positive (Darwinian) selection seems to be acting on the ligand-binding domains of these molecules, suggesting a selection pattern similar to that previously observed in the MHC proteins. In sharp contrast to TLRs, the biological significance of mannan-binding lectin (MBL) is controversial, and, concerning humans, it has been suggested that low concentration of MBL in serum represents a selective advantage. In this mini-review, based on a doctoral thesis, evolutionary aspects of TLRs and MBL are discussed.

Place, publisher, year, edition, pages
2011. Vol. 116, no 2, p. 90-99
Keywords [en]
Innate immunity, MBL, molecular biology, positive selection, recognition, TLRs
National Category
Natural Sciences
Research subject
Natural Science, Biomedical Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-11505DOI: 10.3109/03009734.2010.545494ISI: 000289467100002Scopus ID: 2-s2.0-79954515830OAI: oai:DiVA.org:lnu-11505DiVA, id: diva2:413737
Available from: 2011-04-29 Created: 2011-04-29 Last updated: 2017-12-11Bibliographically approved

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Bergman, Ingrid-Maria

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