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How should blood rheology be measured in macroglobulinaemia?
Department of Clinical Physiology, Central Hospital, Växjö, Sweden.
Department of Medicine, University Hospital, Lund, Sweden.
Department of Medicine, Central Hospital, Karlskrona, Sweden.
1998 (English)In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, Vol. 58, 669-676 p.Article in journal (Refereed) Published
Abstract [en]

Abstract

Blood and plasma viscosity were measured in 13 patients with monoclonal macroglobulinaemia. Blood viscosity was measured at natural hematocrit and after adjustment to 45%. Studies were performed at three different temperatures, +24oC, +32oC and +37oC. Plasma viscosity was measured in a rotational viscometer and in a capillary tube at the above-mentioned temperatures. Blood viscosity was to some extent related to the patients' symptoms, whereas a correlation between blood and plasma viscosity became less pronounced with decreasing shear rates, indicating that plasma viscosity is not a perfect indicator of blood viscosity in macroglobulinaemia. It was shown that red cell concentration, besides the concentration of monoclonal immunoglobulins (= paraproteins (PP)), is an important determinant of blood viscosity. The correlation between red cell concentration and viscosity became stronger with decreasing shear rate. Whole blood viscosity at low shear rates seems to be the best indicator of rheological symptoms in patients with macroglobulinaemia. It is concluded that blood rheology in patients with macroglobulinaernia is best studied at + 32°C to + 37°C in whole blood and at low shear rates.

Key words: Blood viscosity; Hematocrit: Hyperviscosity syndrome; Hypervolemia; IgM; Immunoglobulins; Monoclonal; Plasma viscosity; Waldenström´s disease.

Place, publisher, year, edition, pages
Norway, 1998. Vol. 58, 669-676 p.
Keyword [en]
Blood viscosity; Hematocrit: Hyperviscosity syndrome; Hypervolemia; IgM; Immunoglobulins; Monoclonal; Plasma viscosity; Waldenström´s disease.
National Category
Medical and Health Sciences
Research subject
Natural Science, Biomedical Sciences; Health and Caring Sciences, Caring Science
Identifiers
URN: urn:nbn:se:lnu:diva-11660OAI: oai:DiVA.org:lnu-11660DiVA: diva2:416444
Available from: 2011-05-11 Created: 2011-05-11 Last updated: 2011-09-20Bibliographically approved

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Persson, Sylvi Ulrika
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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
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  • de-DE
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  • Other locale
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