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Changes of blood viscosity in pateints treated with 5-fluorouracil: A link to cardiotoxicity?
Department of Oncology, University Hospital, Lund. Sweden.
Department of Internal Medicine, University Hospital, Lund, Sweden.
Department of Internal Medicine, University Hospital, Lund, Sweden.
Department of Oncology, University Hospital, Lund. Sweden.
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1995 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 34, no 1, 83-85 p.Article in journal (Refereed) Published
Abstract [en]

Abstract

 Cardiotoxicity is a serious but relatively unknown side-effect of treatment with 5-fluorouracil (5-FU). The underlying mechanism of 5-FU cardiotoxicity has not been defined. The aim of the present study was to determine whether hemorheological factors might in part explain 5-FU cardiotoxicity. Changes of blood and plasma viscosity, fibrinogen and hematocrit were studied in 11 patients treated by 5-FU.

The study showed a decrease in blood and plasma viscosity during treatment with 5-FU, probably caused by a decrease of plasma fibrinogen. Reversible cardiotoxic effects were demonstrated in four patients.

Place, publisher, year, edition, pages
Norway, 1995. Vol. 34, no 1, 83-85 p.
Keyword [en]
Cardiotoxicity; Blood viscosity; Fluorouracil; Head and neck neoplasms; Drug therapy;
National Category
Medical and Health Sciences
Research subject
Natural Science, Biomedical Sciences; Health and Caring Sciences, Caring Science
Identifiers
URN: urn:nbn:se:lnu:diva-11712OAI: oai:DiVA.org:lnu-11712DiVA: diva2:417292
Available from: 2011-05-16 Created: 2011-05-16 Last updated: 2011-09-16Bibliographically approved

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Persson, Sylvi Ulrika
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