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Increase in blood pressure as a reaction to insulin treatment in type 2 diabetes
Department of Health Sciences, Växjö University, Sweden.
1999 (English)In: 13th Scientific Meeting, The Inter-American Society of Hypertension, Buenos Aires, Argentina, May 7-11, 1999, 1999Conference paper, Published paper (Refereed)
Abstract [en]

Abstract

BACKGROUND: The institution of insulin therapy may be easy and uncomplicated in some Type 2 diabetics, but in others, mainly the obese patients, problems often arise (e.g. poor compliance, worsening B-cell function and/or insulin resistance).  

METHODS: As a substudy of a broader investigation, concerning hemorheological effects of insulin treatment in insufficiently controlled type 2 diabetics, blood pressure was recorded in 12 patients at baseline, after two months and after four months on insulin.

RESULTS: After two months on insulin analyses of triglycerides, high density lipoprotein cholesterol and total cholesterol indicated metabolic improvement (p<0.05 to 0.001) and a surprisingly uniform increase of blood pressure values (p<0.05 to 0.01) was found. At the same time, the serum sodium concentration increased (p<0.01) and was positively correlated to both systolic and diastolic blood pressure (p<0.01).

After four months on insulin, blood pressure returned to pre-treatment values or even lower (p<0.05 to 0.01). Serum sodium also decreased to pretreatment values. No significant changes of the flow behaviour of blood were seen after institution of insulin.

CONCLUSIONS: The number of patients was small and the study was not primarily designed to examine blood pressure. The preliminary conclusion from this study, however, is that the initiation of insulin treatment in poorly controlled type 2 diabetics causes a temporary and possibly clinically significant elevation of blood pressure. A changed renal handling of sodium caused by insulin, may be one of several possible explanations to the results, but further studies are warranted to confirm the findings.

 

Place, publisher, year, edition, pages
1999.
Keywords [en]
Blood pressure; Insulin therapy; NIDDM; Sodium excretion.
National Category
Medical and Health Sciences
Research subject
Natural Science, Biomedical Sciences; Health and Caring Sciences, Caring Science
Identifiers
URN: urn:nbn:se:lnu:diva-11774OAI: oai:DiVA.org:lnu-11774DiVA, id: diva2:418025
Conference
13th Scientific Meeting, The Inter-American Society of Hypertension, Buenos Aires, Argentina, May 7-11, 1999
Available from: 2011-05-19 Created: 2011-05-19 Last updated: 2011-09-20Bibliographically approved

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CiteExportLink to record
Permanent link

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Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf