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Fatty acid composition of the erythrocyte membrane correlates with rheological properties of the erythrocyte in type II diabetics
Department of Medicine, University Hospital, Lund, Sweden.
Department of Medicine, University Hospital, Lund, Sweden.
Department of Medicine, University Hospital, Lund, Sweden.
Department of Medicine, University Hospital, Lund, Sweden.
1991 (English)In: 7th European Conference on Clinical Haemorheology, Southampton, United Kingdom, July 16-19, 1991, 1991Conference paper, Published paper (Refereed)
Abstract [en]

Abstract

The lipid composition of the erythrocyte membrane is said to be of importance for the rheological properties of the cell. 

Methods: Fatty acid composition of phospholipids from the erythrocyte membrane was studied in 7 patients with type II diabetes when changing from tablets to insulin . Besides it was studied whether the composition of t h e membrane, especially the amount of w-3 fatty acids, influenced the filterability of the red cell. Fatty acid analyses were performed by a Varian 3700 Gas Chromatograph. Blood cell filterability was measured in theSt George'sFiltrometer.  

Results: Patients with insufficiently controlled diabetes on oral agents, showed high amounts of fatty acids 16:0, 18:l and 20:4 compared t o the reference group. Increased amounts of 16:0, decreased amounts of 18:2, 20:4 and total PUFA (polyunsaturated fatty acids) were positively related to low RCTT (red cell transit time) when measured before insulin treatment. After insulin treatment only the correlation PUFA/RCTT remained. There were no corresponding findings in the reference group.  

Conclusion: In poorly controlled type II diabetics the fatty acid composition of the red cell membrane is changed and saturated rather than unsaturated fatty acids, correlate with more filterable cells. Small differences of fatty acid composition i n membrane phospholipids do not influence blood cell rheology in healthy subjects.

 

Place, publisher, year, edition, pages
1991.
Identifiers
URN: urn:nbn:se:lnu:diva-11780OAI: oai:DiVA.org:lnu-11780DiVA, id: diva2:418103
Conference
7th European Conference on Clinical Haemorheology, Southampton, United Kingdom, July 16-19, 1991
Available from: 2011-05-19 Created: 2011-05-19 Last updated: 2011-09-14Bibliographically approved

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