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Aggregation of amyloids in a cellular context: modelling and experiment
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (CCBG)ORCID iD: 0000-0001-8696-3104
2011 (English)In: Biochemical Journal, ISSN 0264-6021, E-ISSN 1470-8728, Vol. 438, 415-426 p.Article in journal (Refereed) Published
Abstract [en]

Amyloid-related diseases are a group of illnesses in which an abnormal accumulation of proteins into fibrillar structures is evident. Results from a wide range of studies, ranging from identification of amyloid-β dimers in the brain to biophysical characterization of the interactions between amyloidogenic peptides and lipid membranes during fibril growth shed light on the initial events which take place during amyloid aggregation. Accounts of fibril disaggregation and formation of globular aggregates due to interactions with lipids or fatty acids further demonstrate the complexity of the aggregation process and the difficulty to treat amyloid-related diseases. There is an inherent difficulty in generalizing from studies of aggregation in vitro, but the involvement of too many cellular components limits the ability to follow amyloid aggregation in a cellular (or extracellular) context. Fortunately, the development of experimental methods to generate stable globular aggregates suggests new means of studying the molecular events associated with amyloid aggregation. Furthermore, simulation studies enable deeper understanding of the experimental results and provide useful predictions that can be tested in the laboratory. Computer simulations can nowadays provide molecular or even atomistic details that are experimentally not available or very difficult to obtain. In the present review, recent developments on modelling and experiments of amyloid aggregation are reviewed, and an integrative account on how isolated interactions (as observed in vitro and in silico) combine during the course of amyloid-related diseases is presented. Finally, it is argued that an integrative approach is necessary to get a better understanding of the protein aggregation process.

Place, publisher, year, edition, pages
2011. Vol. 438, 415-426 p.
Keyword [en]
Alzheimer's disease, computer simulation, integrative biology, molecular dynamics, Parkinson's disease.
National Category
Biochemistry and Molecular Biology
Research subject
Natural Science
Identifiers
URN: urn:nbn:se:lnu:diva-14216DOI: 10.1042/BJ20110369OAI: oai:DiVA.org:lnu-14216DiVA: diva2:445533
Available from: 2011-10-04 Created: 2011-09-16 Last updated: 2016-04-25Bibliographically approved

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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
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  • asciidoc
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