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Adherence, therapeutic intensity, and the number of dispensed drugs
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (eHälsoinstitutet ; eHealth Institute)ORCID iD: 0000-0002-6648-8702
Linnaeus University, Faculty of Health, Social Work and Behavioural Sciences, School of Health and Caring Sciences. (eHälsoinstitutet ; eHealth Institute)ORCID iD: 0000-0002-4295-7201
2011 (English)In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 20, no 12, 1255-1261 p.Article in journal (Refereed) Published
Abstract [en]

Purpose

To estimate non-adherence in relation to the therapeutic intensity (TI) and the number of dispensed drugs per individual and studywhether the TI can be used as an estimator of non-adherence with an increasing number of drugs.

Methods

The study comprised an individual-based register of all dispensed outpatient prescriptions in Sweden in 2006, including6.2 million individuals. The applied definition of drug was the chemical entity or substance comprising the fifth level in the World HealthOrganisation’s Anatomic, Therapeutic, Chemical classification. The defined daily dosage per individual during 12 months was applied asan indicator of the TI.

Results

We found a positive linear relation between the TI and the increasing number of dispensed drugs per individual, both for men andwomen. We found a slightly diminishing TI with an increasing number of drugs only for the age groups above 70 years, at a level above 13drugs per individual.

Conclusions

The linear relationship between the TI and the increasing number of dispensed drugs per individual provides poor support forusing decreasing TI as an estimator of non-adherence. The low rate of cost-related non-adherence in Sweden might contribute to explainingthe linear relationship.

Place, publisher, year, edition, pages
2011. Vol. 20, no 12, 1255-1261 p.
National Category
Pharmacology and Toxicology
Research subject
Biomedical Sciences, Pharmacology
Identifiers
URN: urn:nbn:se:lnu:diva-14695DOI: 10.1002/pds.2230OAI: oai:DiVA.org:lnu-14695DiVA: diva2:445568
Available from: 2011-10-04 Created: 2011-10-04 Last updated: 2017-01-19Bibliographically approved

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Publisher's full texthttp://onlinelibrary.wiley.com/doi/10.1002/pds.2230/abstract

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CiteExportLink to record
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Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
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