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Towards a synthetic avidin mimic
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (BBCG ; BBCL)
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (BBCG ; BBCL ; PPL ; BMC)ORCID iD: 0000-0002-7392-0591
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (BBCL)ORCID iD: 0000-0002-0407-6542
2011 (English)In: Analytical and Bioanalytical Chemistry, ISSN 1618-2642, E-ISSN 1618-2650, Vol. 400, no 5, p. 1397-1404Article in journal (Refereed) Published
Abstract [en]

A series of streptavidin-mimicking molecularly imprinted polymers has been developed and evaluated for their biotin binding characteristics. A combination of molecular dynamics and NMR spectroscopy was used to examine potential polymer systems, in particular with the functional monomers methacrylic acid and 2-acrylamidopyridine. The synthesis of copolymers of ethylene dimethacrylate and one or both of these functional monomers was performed. A combination of radioligand binding studies and surface area analyses demonstrated the presence of selectivity in polymers prepared using methacrylic acid as the functional monomer. This was predicted by the molecular dynamics studies showing the power of this methodology as a prognostic tool for predicting the behavior of molecularly imprinted polymers.

Place, publisher, year, edition, pages
2011. Vol. 400, no 5, p. 1397-1404
National Category
Analytical Chemistry Organic Chemistry Polymer Chemistry Theoretical Chemistry
Research subject
Chemistry, Organic Chemistry
Identifiers
URN: urn:nbn:se:lnu:diva-16275DOI: 10.1007/s00216-011-4907-5Scopus ID: 2-s2.0-79955560945OAI: oai:DiVA.org:lnu-16275DiVA, id: diva2:468582
Available from: 2011-12-21 Created: 2011-12-21 Last updated: 2017-12-08Bibliographically approved

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Wiklander, Jesper G.Karlsson, Björn C. G.Nicholls, Ian A.

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CiteExportLink to record
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Citation style
  • apa
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  • ieee
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  • vancouver
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More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
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  • Other locale
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Output format
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