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Long-Term Storage of Surface-Adsorbed Protein Machines
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.ORCID iD: 0000-0002-5889-7792
2011 (English)In: Langmuir, ISSN 0743-7463, E-ISSN 1520-5827, Vol. 27, no 11, p. 7108-7112Article in journal (Refereed) Published
Abstract [en]

The effective and simple long-term storage of complex functional proteins is critical in achieving commercially viable biosensors. This issue is particularly challenging in recently proposed types of nanobiosensors, where molecular-motor-driven transportation substitutes microfluidics and forms the basis for novel detection schemes. Importantly, therefore, we here describe that delicate heavy meromyosin (HMM)-based nanodevices (HMM motor fragments adsorbed to silanized surfaces and actin bound to HMM) fully maintain their function when stored at -20 degrees C for more than a month. The mechanisms for the excellent preservation of acto-HMM motor function upon repeated freeze thaw cycles are discussed. The results are important to the future commercial implementation of motor-based nanodevices and are of more general value to the long-term storage of any protein-based bionanodevice.

Place, publisher, year, edition, pages
2011. Vol. 27, no 11, p. 7108-7112
National Category
Biophysics
Research subject
Natural Science, Biomedical Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-16473DOI: 10.1021/la201081wScopus ID: 2-s2.0-79957992712OAI: oai:DiVA.org:lnu-16473DiVA, id: diva2:471479
Funder
Swedish Research Council, 621-2010-5146EU, FP7, Seventh Framework Programme, NMP4-SL-2009-228971Available from: 2012-01-02 Created: 2012-01-02 Last updated: 2017-12-08Bibliographically approved

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Albet-Torres, NuriaMånsson, Alf

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CiteExportLink to record
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  • apa
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  • de-DE
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  • nn-NB
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  • Other locale
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