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High complement factor I activity in the plasma of children with autism spectrum disorders
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
Kalmar County Hospital.
University of Social Welfare and rehabilitation Sciences, Iran.
Lund University.
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2012 (English)In: Autism Research and Treatment, ISSN 2090-1925, E-ISSN 2090-1933, 868576Article in journal (Refereed) Published
Abstract [en]

Autism spectrum disorders (ASDs) are neurodevelopmental and behavioural syndromes affecting social orientation, behaviour, and communication that can be classified as developmental disorders. ASD is also associated with immune system abnormality. Immune system abnormalities may be caused partly by complement system factor I deficiency. Complement factor I is a serine protease present in human plasma that is involved in the degradation of complement protein C3b, which is a major opsonin of the complement system. Deficiency in factor I activity is associated with an increased incidence of infections in humans. In this paper, we show that the mean level of factor I activity in the ASD group is significantly higher than in the control group of typically developed and healthy children, suggesting that high activity of complement factor I might have an impact on the development of ASD.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2012. 868576
Keyword [en]
Factor I, Autism Spectrum Disorders, ASD
National Category
Immunology in the medical area Neurology
Research subject
Natural Science, Biomedical Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-16722DOI: 10.1155/2012/868576OAI: oai:DiVA.org:lnu-16722DiVA: diva2:476148
Projects
Autism spectrum disorders
Available from: 2012-01-11 Created: 2012-01-11 Last updated: 2016-07-21Bibliographically approved

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Momeni, NaghiPersson, Bengt L.
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