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Spectroscopic evidence for the presence of the cyclic hemiketal form of warfarinin aqueous solution: Consequences for bioavailability
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (BBCL ; PPL ; BMC)ORCID iD: 0000-0002-7392-0591
2011 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 407, no 2, 318-320 p.Article in journal (Refereed) Published
Abstract [en]

Warfarin is an important oral anticoagulant drug that demonstrates a molecular-environment dependent structural diversity. Previous investigations of warfarin’s ensemble of isomers in organic solvent-based environments have pointed to the importance of the closed-ring cyclic hemiketal form of the drug in non-polar environments, e.g. the interior of proteins, enzymes and biomembranes. Detection of the presence of these isomers in polar environments has not yet been reported. Here, we demonstrate the presence of the cyclic hemiketal structural form of warfarin under aqueous conditions. This finding underscores the importance considering all structural isomers of this drug when making predictions on warfarin’s bioavailability.

Place, publisher, year, edition, pages
2011. Vol. 407, no 2, 318-320 p.
National Category
Chemical Sciences
Research subject
Chemistry, Organic Chemistry
Identifiers
URN: urn:nbn:se:lnu:diva-16768DOI: 10.1016/j.bbrc.2011.03.010OAI: oai:DiVA.org:lnu-16768DiVA: diva2:477340
Available from: 2012-01-13 Created: 2012-01-13 Last updated: 2017-02-10Bibliographically approved

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Rosengren, Annika M.Karlsson, Björn C. G.
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Citation style
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  • Other locale
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