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Familial dyslexia in a large Swedish family: A whole genome linkage scan
Linnaeus University, Faculty of Health, Social Work and Behavioural Sciences, School of Education, Psychology and Sport Science.ORCID iD: 0000-0003-2608-6204
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2011 (English)In: Behavior Genetics, ISSN 0001-8244, E-ISSN 1573-3297, Vol. 41, no 1, 43-49 p.Article in journal (Refereed) Published
Abstract [en]

There is a compelling body of evidence that developmental dyslexia runs in families and seems to be highly inheritable. Several investigations during the last two decades have shown possible locations of genes that might be involved in dyslexia, including regions of chromosomes 1, 2, 3, 6, 11, 13, 15 and 18. In addition, six candidate genes (KIAA0319, DYX1C1, DCDC2, ROBO1, MRPL19 and C2ORF3) seem to be related to dyslexia. The present study carried out a whole genome scan in a six-generation pedigree. In addition to literacy skills the assessment included cognitive skills and records concerning the history of reading and writing ability. Thirty-five percent were regarded as dyslexic in the family. A linkage analysis using both a quantitative and a qualitative approach has been performed. No evidence was obtained to support the hypothesis that the transmission of dyslexia in this pedigree is due to a highly penetrant major gene, and previous linkage findings were not replicated; however, power in this small study was not adequate to confirm linkage of genes with small to moderate effects. The results were discussed in relation to diagnostic procedures and sample characteristics.

Place, publisher, year, edition, pages
2011. Vol. 41, no 1, 43-49 p.
National Category
Social Sciences
Research subject
Social Sciences, Psychology
Identifiers
URN: urn:nbn:se:lnu:diva-16810DOI: 10.1007/s10519-010-9395-4OAI: oai:DiVA.org:lnu-16810DiVA: diva2:477714
Available from: 2012-01-13 Created: 2012-01-13 Last updated: 2017-01-16Bibliographically approved

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CiteExportLink to record
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Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
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