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A factor analytic approach to symptom patterns in dementia
Lund University.
Lund University.
Lund University.
Lund University.
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2011 (English)In: International Journal of Alzheimer's Disease, ISSN 2090-8024, E-ISSN 2090-0252, article id 632604Article in journal (Refereed) Published
Abstract [en]

Previous publications have shown a high diagnostic sensitivity and specificity of three short clinical rating scales for Alzheimer's disease (AD), frontotemporal dementia (FTD), and vascular dementia (VaD) validated against neuropathological (NP) diagnoses. In this study, the aim was to perform an exploratory factor analysis of the items in these clinical rating scales. The study included 190 patients with postmortem diagnoses of AD ( 𝑛=74), VaD (𝑛=33), mixed AD/VaD (𝑛=31), or FTD (𝑛=52). The factor analysis produced three strong factors. Factor 1 contained items describing cerebrovascular disease, similar to the Hachinski Ischemic Score. Factor 2 enclosed major clinical characteristics of FTD, and factor 3 showed a striking similarity to the AD scale. A fourth symptom cluster was described by perception and expression of emotions. The factor analyses strongly support the construct validity of the diagnostic rating scales.

Place, publisher, year, edition, pages
2011. article id 632604
National Category
Psychology
Research subject
Social Sciences, Psychology
Identifiers
URN: urn:nbn:se:lnu:diva-16830DOI: 10.4061/2011/632604OAI: oai:DiVA.org:lnu-16830DiVA, id: diva2:478410
Available from: 2012-01-16 Created: 2012-01-16 Last updated: 2017-12-08Bibliographically approved

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Warkentin, Siegbert

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