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Cube copying test in combination with rCBF or CSF A-beta-42 predicts development of Alzheimer´s disease.
Linnaeus University, Faculty of Health, Social Work and Behavioural Sciences, School of Education, Psychology and Sport Science.
Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund & Neuropsychiatric Clinic, Malmö University Hospital, Malmö ,.
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2008 (English)In: Dementia and Geriatric Cognitive Disorders, Vol. 25, 544-552 p.Article in journal (Refereed) Published
Abstract [en]

Background/Aim: The aim was to identify subjects with incipientAlzheimer’s disease (AD) among patients with mildcognitive impairment (MCI) using brief cognitive tests. Methods:A total of 147 MCI patients were followed for 4–6 yearsand the incidence of AD was 11.6%/year. At baseline, thecube copying test, clock drawing test, MMSE and measurementsof regional cerebral blood flow (rCBF) and cerebrospinalfluid (CSF) -amyloid 1–42 (A 42 ) were performed. Results:The cube copying test, but not the clock drawing test, couldpredict AD among MCI patients with an area under the receiveroperating characteristic curve of 0.64 (p ! 0.01). Therelative risk for future AD was increased in MCI subjects withimpaired cube copying test (sex- and age-adjusted hazardratio = 1.8, p ! 0.05) and the incidence of AD was 18.2% inthis subgroup. Combining the cube copying test with eitherrCBF or CSF A 4 2 had additive effects on the risk assessmentfor future development of AD. MCI patients achieving highscores on both MMSE and cube copying test had a very lowrisk of developing AD (incidence of AD = 1.6%). Conclusion:In conclusion, combinations of the cube copying test withMMSE, rCBF and CSF A 4 2 measurements can identify subgroupsof MCI subjects with either substantially reduced orincreased risk for future development of AD.

Place, publisher, year, edition, pages
2008. Vol. 25, 544-552 p.
National Category
Psychology
Research subject
Social Sciences, Psychology
Identifiers
URN: urn:nbn:se:lnu:diva-16852DOI: 10.1159/000137379OAI: oai:DiVA.org:lnu-16852DiVA: diva2:478947
Available from: 2012-01-17 Created: 2012-01-17 Last updated: 2013-07-18Bibliographically approved

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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf