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A novel blood-based biomarker for detection of autism spectrum disorders
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (Bengt Persson)
Uppsala University.
Kalmar County Hospital.
University of Social Welfare and Rehabilitation Sciences, Iran.
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2012 (English)In: Translational Psychiatry, ISSN 2158-3188, E-ISSN 2158-3188, Vol. 2, article id e91Article in journal (Refereed) Published
Abstract [en]

Autism Spectrum Disorders (ASD) are classified as neurological developmental disorders. Several studies have been carried out to find a candidate biomarker linked to development of these disorders, but up to date no reliable biomarker is available. Mass spectrometry techniques have been used for protein profiling of blood plasma of children with such disorders in order to identify proteins/peptides which may be used as biomarkers for detection of the disorders. Three differentially expressed peptides with mass charged (m/z) values of 2,020 ± 1, 1,864 ± 1, and 1,978 ± 1 Da in heparin plasma of children with ASD which were significantly changed as compared to the peptide pattern of the non-ASD control group are reported here. This novel set of biomarkers allows for a reliable blood based diagnostic tool that may be used in diagnosis and potentially, in prognosis of ASD. 

Place, publisher, year, edition, pages
Nature Publishing Group, 2012. Vol. 2, article id e91
Keywords [en]
ASD, autism spectrum disorders, biomarker, blood
National Category
Neurology Biochemistry and Molecular Biology
Research subject
Natural Science, Biomedical Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-18964DOI: 10.1038/tp.2012.19Scopus ID: 2-s2.0-84858021906OAI: oai:DiVA.org:lnu-18964DiVA, id: diva2:528925
Available from: 2012-05-28 Created: 2012-05-28 Last updated: 2017-12-07Bibliographically approved

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Momeni, NaghiPersson, Bengt L.

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CiteExportLink to record
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