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Evaluation of the blood compatibility of materials, cells and tissues: Basic concepts, test models and practical guidelines
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Uppsala Univ. (BMC)ORCID iD: 0000-0001-7888-1571
Uppsala University.
Uppsala University.
Uppsala University.
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2013 (English)In: Complement Therapeutics / [ed] J.D. Lambris, V.M. Holers & D. Ricklin, Springer, 2013, 257-270 p.Chapter in book (Refereed)
Abstract [en]

Medicine today uses a wide range of biomaterials, most of which make contact with blood permanently or transiently upon implantation. Contact between blood and nonbiological materials or cells or tissue of nonhematologic origin initiates activation of the cascade systems (complement, contact activation/coagulation) of the blood, which induces platelet and leukocyte activation.

Although substantial progress regarding biocompatibility has been made, many materials and medical treatment procedures are still associated with severe side effects. Therefore, there is a great need for adequate models and guidelines for evaluating the blood compatibility of biomaterials. Due to the substantial amount of cross talk between the different cascade systems and cell populations in the blood, it is advisable to use an intact system for evaluation.

Here, we describe three such in vitro models for the evaluation of the biocompatibility of materials and therapeutic cells and tissues. The use of different anticoagulants and specific inhibitors in order to be able to dissect interactions between the different cascade systems and cells of the blood is discussed. In addition, we describe two clinically relevant medical treatment modalities, the integration of titanium implants and transplantation of islets of Langerhans to patients with type 1 diabetes, whose mechanisms of action we have addressed using these in vitro models.

Place, publisher, year, edition, pages
Springer, 2013. 257-270 p.
Series
Advances in Experimental Medicine and Biology, ISSN 0065-2598 ; Vol 735
National Category
Biochemistry and Molecular Biology Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Research subject
Natural Science, Biomedical Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-18984DOI: 10.1007/978-1-4614-4118-2_18ISI: 000333837700019ISBN: 978-1-4614-4117-5 (print)ISBN: 978-1-4614-4118-2 (print)OAI: oai:DiVA.org:lnu-18984DiVA: diva2:529016
Available from: 2012-05-28 Created: 2012-05-28 Last updated: 2017-02-16Bibliographically approved

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Nilsson Ekdahl, Kristina
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CiteExportLink to record
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Citation style
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