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Self-organization of motor-propelled cytoskeletal filaments at topographically defined borders.
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.ORCID iD: 0000-0002-5889-7792
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
2012 (English)In: Journal of Biomedicine and Biotechnology, ISSN 1110-7243, E-ISSN 1110-7251, Vol. 2012, p. Article ID: 647265-Article in journal (Refereed) Published
Abstract [en]

Self-organization phenomena are of critical importance in living organisms and of great interest to exploit in nanotechnology. Here we describe in vitro self-organization of molecular motor-propelled actin filaments, manifested as a tendency of the filaments to accumulate in high density close to topographically defined edges on nano- and microstructured surfaces. We hypothesized that this "edge-tracing" effect either (1) results from increased motor density along the guiding edges or (2) is a direct consequence of the asymmetric constraints on stochastic changes in filament sliding direction imposed by the edges. The latter hypothesis is well captured by a model explicitly defining the constraints of motility on structured surfaces in combination with Monte-Carlo simulations [cf. Nitta et al. (2006)] of filament sliding. In support of hypothesis 2 we found that the model reproduced the edge tracing effect without the need to assume increased motor density at the edges. We then used model simulations to elucidate mechanistic details. The results are discussed in relation to nanotechnological applications and future experiments to test model predictions.

Place, publisher, year, edition, pages
2012. Vol. 2012, p. Article ID: 647265-
National Category
Biophysics
Research subject
Natural Science, Biomedical Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-19188DOI: 10.1155/2012/647265ISI: 000302684600001PubMedID: 22536023Scopus ID: 2-s2.0-84859733273OAI: oai:DiVA.org:lnu-19188DiVA, id: diva2:530036
Funder
Swedish Research Council, 621-2010-5146EU, FP7, Seventh Framework Programme, NMP4-SL-2009-228971Available from: 2012-05-31 Created: 2012-05-31 Last updated: 2017-12-07Bibliographically approved

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Månsson, Alf

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