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Autoregulation of thromboinflammation on biomaterial surfaces by a multicomponent therapeutic coating.
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.ORCID iD: 0000-0002-7192-5794
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. (BMC)ORCID iD: 0000-0001-7888-1571
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2013 (English)In: Biomaterials, ISSN 0142-9612, E-ISSN 1878-5905, Vol. 34, no 4, 985-994 p.Article in journal (Refereed) Published
Abstract [en]

Activation of the thrombotic and complement systems is the main recognition and effector mechanisms in the multiple adverse biological responses triggered when biomaterials or therapeutic cells come into blood contact. We have created a surface which is auto-protective to human innate immunity by combining three fundamentally different strategies, all developed by us previously, which have been shown to induce substantial, but incomplete hemocompatibility when used separately. In summary, we have conjugated a factor H-binding peptide; and an ADP-degrading enzyme; using a PEG linker on both material and cellular surfaces. When exposed to human whole blood, factor H was specifically recruited to the modified surfaces and inhibited complement attack. In addition, activation of platelets and coagulation was efficiently attenuated, by degrading ADP. Thus, by inhibiting thromboinflammation using a multicomponent approach, we have created a hybrid surface with the potential to greatly reduce incompatibility reactions involving biomaterials and transplantation.

Place, publisher, year, edition, pages
2013. Vol. 34, no 4, 985-994 p.
National Category
Biological Sciences
Research subject
Natural Science, Biomedical Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-22802DOI: 10.1016/j.biomaterials.2012.10.040ISI: 000313155800014PubMedID: 23137394OAI: oai:DiVA.org:lnu-22802DiVA: diva2:576316
Available from: 2012-12-12 Created: 2012-12-12 Last updated: 2017-03-22Bibliographically approved

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Nilsson, Per H.Nilsson Ekdahl, Kristina
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CiteExportLink to record
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