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Further assessment of neuropathology in retinal explants and neuroprotection by human neural progenitor cells.
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (Retinal research)
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
2011 (English)In: Journal of Neural Engineering, ISSN 1741-2560, Vol. 8, no 6, Article ID: 066012- p.Article in journal (Refereed) Published
Abstract [en]

Explanted rat retinas show progressive photoreceptor degeneration that appears to be caspase-12-dependent. Decrease in photoreceptor density eventually affects the inner retina, particularly in the bipolar cell population. Explantation and the induced photoreceptor degeneration are accompanied by activation of Müller and microglia cells. The goal of this study was to determine whether the presence of a feeder layer of human neural progenitor cells (hNPCs) could suppress the degenerative and reactive changes in the explants. Immunohistochemical analyses showed considerable sprouting of rod photoreceptor axon terminals into the inner retina and reduced densities of cone and rod bipolar cells. Both sprouting and bipolar cell degenerations were significantly lower in retinas cultured with feeder layer cells compared to cultured controls. A tendency toward reduced microglia activation in the retinal layers was also noted in the presence of feeder layer cells. These results indicate that hNPCs or factors produced by them can limit the loss of photoreceptors and secondary injuries in the inner retina. The latter may be a consequence of disrupted synaptic arrangement.

Place, publisher, year, edition, pages
2011. Vol. 8, no 6, Article ID: 066012- p.
National Category
Natural Sciences
Research subject
Natural Science, Biomedical Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-23051DOI: 10.1088/1741-2560/8/6/066012OAI: oai:DiVA.org:lnu-23051DiVA: diva2:579090
Available from: 2012-12-19 Created: 2012-12-19 Last updated: 2014-02-03Bibliographically approved
In thesis
1. Neural progenitor cell-derived neurotrophic support for the degenerating retina: an in vitro study
Open this publication in new window or tab >>Neural progenitor cell-derived neurotrophic support for the degenerating retina: an in vitro study
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Växjö: Linnaeus University press, 2013. 77 p.
Series
Linnaeus University Dissertations, 158
Keyword
retinal degeneration, apoptosis, retina, ER-stress, autophagy
National Category
Natural Sciences
Research subject
Natural Science, Biomedical Sciences
Identifiers
urn:nbn:se:lnu:diva-31164 (URN)978-91-87427-67-1 (ISBN)
Public defence
2013-12-20, N2007, Västergård, Kalmar, 09:00 (Swedish)
Opponent
Supervisors
Available from: 2014-02-03 Created: 2013-12-10 Last updated: 2014-02-03Bibliographically approved

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Publisher's full texthttp://iopscience.iop.org/1741-2552/8/6/066012/

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CiteExportLink to record
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