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Complement Diagnostics: Concepts, Indications, and Practical Guidelines
Uppsala University.
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. Uppsala University.ORCID iD: 0000-0001-7888-1571
2012 (English)In: Clinical & Developmental Immunology, ISSN 1740-2522, E-ISSN 1740-2530, 962702Article, review/survey (Refereed) Published
Abstract [en]

Aberrations in the complement system have been shown to be direct or indirect pathophysiological mechanisms in a number of diseases and pathological conditions such as autoimmune disease, infections, cancer, allogeneic and xenogeneic transplantation, and inflammation. Complement analyses have been performed on these conditions in both prospective and retrospective studies and significant differences have been found between groups of patients, but in many diseases, it has not been possible to make predictions for individual patients because of the lack of sensitivity and specificity of many of the assays used. The basic indications for serological diagnostic complement analysis today may be divided into three major categories: (a) acquired and inherited complement deficiencies; (b) disorders with complement activation; (c) inherited and acquired C1INH deficiencies. Here, we summarize indications, techniques, and interpretations for basic complement analyses and present an algorithm, which we follow in our routine laboratory.

Place, publisher, year, edition, pages
2012. 962702
National Category
Immunology
Research subject
Biomedical Sciences, Immunology
Identifiers
URN: urn:nbn:se:lnu:diva-23367DOI: 10.1155/2012/962702ISI: 000311576600001OAI: oai:DiVA.org:lnu-23367DiVA: diva2:584673
Available from: 2013-01-09 Created: 2013-01-09 Last updated: 2016-11-11Bibliographically approved

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Nilsson Ekdahl, Kristina
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