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Enteroviral Central Nervous System Infections in Children of the Region of Monastir, Tunisia: Diagnosis, Laboratory Findings of Cerebrospinal Fluid and Clinical Manifestations
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2012 (English)In: Indian Journal of Virology, ISSN 0970-2822, Vol. 23, no 3, 294-302 p.Article in journal (Refereed) Published
Abstract [en]

Human enteroviruses (HEV) are one of the major causes of central nervous system (CNS) infections in pediatrics. A prospective study was conducted to assess the epidemiological, clinical, and laboratory characteristics of enterovirus (EV) infections of the CNS in children under 15-years-old, suspected of having viral CNS infections and admitted to the Pediatric Department of Monastir University Hospital, Tunisia. Enteroviral RNA was detected by 5' NCR nested RT-PCR assay in 33 % (20 out of 60) of cerebrospinal fluid specimens, whereas only six samples (10 %) were EV positive in cell culture. EV-positive patients were clustered according to their clinical manifestations, predominantly diagnosed as aseptic meningitis (65 %) and meningoencephalitis (20 %). Fever, headache, vomiting, and neck stiffness were the most pronounced symptoms. Pleocytosis with the predominance of lymphocytes was observed in 60 % of EV positive specimens. Although patients suffering from EV infections were encountered throughout the year, most occurred during spring and summer months. Using VP1-2A nested RT-PCR and sequence analysis, three of the 20 positive HEV were identified as Echovirus (E)-9. This is the first report of a cluster of aseptic meningitis cases caused by E-9 in Monastir.

Place, publisher, year, edition, pages
2012. Vol. 23, no 3, 294-302 p.
Keyword [en]
Enterovirus, Cerebrospinal fluid, Children, Molecular typing, Epidemiology
National Category
Microbiology
Research subject
Biomedical Sciences, Virology
Identifiers
URN: urn:nbn:se:lnu:diva-23373DOI: 10.1007/s13337-012-0104-1ISI: 000312076000006OAI: oai:DiVA.org:lnu-23373DiVA: diva2:584717
Available from: 2013-01-09 Created: 2013-01-09 Last updated: 2016-10-05Bibliographically approved

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Gullberg, MariaLindberg, A. Michael
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CiteExportLink to record
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Citation style
  • apa
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  • ieee
  • modern-language-association-8th-edition
  • vancouver
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More styles
Language
  • de-DE
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  • nn-NB
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