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Monitoring of the distribution of warfarin in blood plasma
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (BBCL)
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (PPL ; BMC)ORCID iD: 0000-0002-7392-0591
Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences. (BBCL)ORCID iD: 0000-0002-0407-6542
2012 (English)In: ACS Medicinal Chemistry Letters, ISSN 1948-5875, E-ISSN 1948-5875, Vol. 3, no 8, 650-652 p.Article in journal (Refereed) Published
Abstract [en]

Warfarin is an anticoagulant drug extensively used in the treatment and prevention of thrombotic disorders. Previous studies have shown that warfarin binds extensively to blood plasma proteins and that only a small fraction of the drug is unbound and thus available for therapeutic function. Both warfarin's narrow therapeutic window and the susceptibility of anticoagulant function to patient-dependent factors necessitate regular monitoring. In this study, we have shown that the lifetimes for each of the various bound and free forms of the drug in blood plasma can be quantified in situ by time-correlated single-photon counting fluorescence spectroscopy over the clinically significant concentration range. A relationship between the blood coagulation and the distribution of fluorescence lifetimes was observed. The in situ detection of clinically relevant concentrations of warfarin in its respective bound and unbound forms could provide a prognostic tool for use in patient treatment.

Place, publisher, year, edition, pages
2012. Vol. 3, no 8, 650-652 p.
National Category
Pharmaceutical Sciences
Research subject
Chemistry, Organic Chemistry
Identifiers
URN: urn:nbn:se:lnu:diva-23377DOI: 10.1021/ml300112eOAI: oai:DiVA.org:lnu-23377DiVA: diva2:584765
Available from: 2013-01-09 Created: 2013-01-09 Last updated: 2017-02-10Bibliographically approved

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Rosengren, Annika M.Karlsson, Björn C. G.Nicholls, Ian A.
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Citation style
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