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Consequences of morphology on molecularly imprinted polymer-ligand recognition
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. (PPL ; BMC ; BBCL)ORCID iD: 0000-0002-7392-0591
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Uppsala University. (BMC ; BBCL)ORCID iD: 0000-0002-0407-6542
2013 (English)In: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 14, no 1, 1207-1217 p.Article in journal (Refereed) Published
Abstract [en]

The relationship between molecularly imprinted polymer (MIP) morphology and template-rebinding over a series of warfarin-imprinted methacrylic acid co(ethylene dimethacrylate) polymers has been explored. Detailed investigations of the nature of template recognition revealed that an optimal template binding was obtained with polymers possessing a narrow population of pores (~3–4 nm) in the mesopore size range. Importantly, the warfarin-polymer rebinding analyses suggest strategies for regulating ligand binding capacity and specificity through variation of the degree of cross-linking, where polymers prepared with a lower degree of cross-linking afford higher capacity though non-specific in character. In contrast, the co-existence of specific and non-specific binding was found in conjunction with higher degrees of cross-linking and resultant meso- and macropore size distributions.

Place, publisher, year, edition, pages
2013. Vol. 14, no 1, 1207-1217 p.
Keyword [en]
molecularly imprinted polymer, MIP, morphology, BET, surface area, warfarin
National Category
Chemical Sciences
Research subject
Chemistry, Organic Chemistry
Identifiers
URN: urn:nbn:se:lnu:diva-23378DOI: 10.3390/ijms14011207ISI: 000314048800071PubMedID: 23303280OAI: oai:DiVA.org:lnu-23378DiVA: diva2:584772
Available from: 2013-01-09 Created: 2013-01-09 Last updated: 2017-02-16Bibliographically approved

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Rosengren, Annika M.Karlsson, Björn C. G.Nicholls, Ian A.
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CiteExportLink to record
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