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The bacterium Candidatus Neoehrlichia mikurensis in ticks from humans
Linnaeus University, Faculty of Health and Life Sciences, Department of Biology and Environmental Science.
2013 (English)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

The bacterium Candidatus Neoehrlichia mikurensis (CNM) is a novel human pathogen that was first discovered on the island of Mikura, Japan, in 2004. In the year 2007 a man in Sweden who had received chemotherapy due to chronic lymphocytic leukemia suffered from a severe infection. After analyzing blood samples from the man it was determined that the infection was due to CNM. This was the first documented human case of CNM infection. Unlike many other bacteria, CNM is not yet possible to cultivate and therefore is hard to detect. Methods used to detect the bacterium are screening for specific gene fragments by PCR and further phylogenetic studies where the DNA-sequences are compared to known documented sequences. Due to the difficulties with detection it is not known if CNM been among us for a long time or if it is just starting to establish. In this study DNA from ticks biting humans was analyzed for the presence of CNM. Ticks were handed in from bitten people to health care centers in Southern Sweden and Åland as part of a large science-project called the STING-study. Out of 836 ticks screened, 68 (8%) were positive for CNM. Looking at the distribution of the ticks in different life stages it was clear that none of the ticks positive for CNM were larvae. This indicates that the bacterium only transmits through blood-meals and that no transovarial transmission occurs. 

Place, publisher, year, edition, pages
2013. , p. 15
Keywords [en]
Candidatus Neoehrlichia mikurensis, human pathogen
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-30395OAI: oai:DiVA.org:lnu-30395DiVA, id: diva2:663975
Subject / course
Biology
Educational program
Biology Programme, 180 credits
Supervisors
Examiners
Available from: 2013-11-14 Created: 2013-11-13 Last updated: 2013-11-14Bibliographically approved

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Citation style
  • apa
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  • en-US
  • fi-FI
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  • nn-NB
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  • Other locale
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Output format
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  • asciidoc
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