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Physical exercise ameliorates deficits induced by traumatic brain injury
Linnaeus University, Faculty of Health, Social Work and Behavioural Sciences, School of Education, Psychology and Sport Science. University of Gothenburg.
Linnaeus University, Faculty of Health, Social Work and Behavioural Sciences, School of Education, Psychology and Sport Science.
Linnaeus University, Faculty of Health, Social Work and Behavioural Sciences, School of Education, Psychology and Sport Science. Mittuniversitetet, Institutionen för hälsovetenskap.ORCID iD: 0000-0001-6653-3414
2012 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 125, no 5, 293-302 p.Article, review/survey (Refereed) Published
Abstract [en]

The extent and depth of traumatic brain injury (TBI) remains a major determining factor together with the type of structural insult and its location, whether mild, moderate or severe, as well as the distribution and magnitude of inflammation and loss of cerebrovascular integrity, and the eventual efficacy of intervention. The influence of exercise intervention in TBI is multiple, ranging from anti-apoptotic effects to the augmentation of neuroplasticity. Physical exercise diminishes cerebral inflammation by elevating factors and agents involved in immunomodulatory function, and buttresses glial cell, cerebrovascular, and blood-brain barrier intactness. It provides unique non-pharmacologic intervention that incorporate different physical activity regimes, whether dynamic or static, endurance or resistance. Physical training regimes ought necessarily to be adapted to the specific demands of diagnosis, type and degree of injury and prognosis for individuals who have suffered TBI. © 2012 John Wiley & Sons A/S.

Place, publisher, year, edition, pages
2012. Vol. 125, no 5, 293-302 p.
Keyword [en]
Anti-apoptosis; Anti-inflammatory; Brain injury; Cerebrovascular; Exercise; Extent; Intervention
National Category
Physiotherapy Neurology
Research subject
Health and Caring Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-33249DOI: 10.1111/j.1600-0404.2011.01638.xISI: 000302347800004Scopus ID: 84859423418OAI: oai:DiVA.org:lnu-33249DiVA: diva2:707522
Available from: 2012-08-22 Created: 2014-03-24 Last updated: 2017-01-25Bibliographically approved

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CiteExportLink to record
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