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C-reactive protein levels in patients at cardiovascular risk: EURIKA study
Cardiff University, Wales ; Swansea University College of Medicine, UK.
Assistance Publique - Hôpitaux de Paris, France.
Assistance Publique - Hôpitaux de Paris, France ; Paris Diderot University, France.
Universidad Autónoma de Madrid, Spain ; Biomedical Research Networking Center for Epidemiology and Public Health (CIBERESP), Spain.
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2014 (English)In: BMC Cardiovascular Disorders, ISSN 1471-2261, E-ISSN 1471-2261, Vol. 14, article id 25Article in journal (Refereed) Published
Abstract [en]

Background: Elevated C-reactive protein (CRP) levels are associated with high cardiovascular risk, and might identify patients who could benefit from more carefully adapted risk factor management. We have assessed the prevalence of elevated CRP levels in patients with one or more traditional cardiovascular risk factors. Methods: Data were analysed from the European Study on Cardiovascular Risk Prevention and Management in Usual Daily Practice (EURIKA, ClinicalTrials. gov Identifier: NCT00882336), which included patients (aged = 50 years) from 12 European countries with at least one traditional cardiovascular risk factor but no history of cardiovascular disease. Analysis was also carried out on the subset of patients without diabetes mellitus who were not receiving statin therapy. Results: In the overall population, CRP levels were positively correlated with body mass index and glycated haemoglobin levels, and were negatively correlated with high- density lipoprotein cholesterol levels. CRP levels were also higher in women, those at higher traditionally estimated cardiovascular risk and those with greater numbers of metabolic syndrome markers. Among patients without diabetes mellitus who were not receiving statin therapy, approximately 30% had CRP levels >= 3 mg/ L, and approximately 50% had CRP levels = 2 mg/ L, including those at intermediate levels of traditionally estimated cardiovascular risk. Conclusions: CRP levels are elevated in a large proportion of patients with at least one cardiovascular risk factor, without diabetes mellitus who are not receiving statin therapy, suggesting a higher level of cardiovascular risk than predicted according to conventional risk estimation systems.

Place, publisher, year, edition, pages
2014. Vol. 14, article id 25
Keywords [en]
C-reactive protein, Cardiovascular disease, Epidemiology, Risk factors/global assessment
National Category
Health Sciences
Research subject
Health and Caring Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-34193DOI: 10.1186/1471-2261-14-25ISI: 000334535900001Scopus ID: 2-s2.0-84895429236OAI: oai:DiVA.org:lnu-34193DiVA, id: diva2:717407
Available from: 2014-05-15 Created: 2014-05-15 Last updated: 2017-12-05Bibliographically approved

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Perk, Joep

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